A new compound that inhibits the activity of alertness-promoting brain peptides called orexins shows promise as a sleeping pill, according to tests in people and animals.
Men who took the drug fell asleep more quickly than did men who took a placebo, neurobiologist François Jenck of Actelion Pharmaceuticals in Allschwil, Switzerland, and his collaborators report in the February Nature Medicine.
Larger doses of the drug act faster and seem to have a stronger effect than do smaller doses, the researchers found. They previously observed similar effects in both dogs and rats.
The duration of drug-induced somnolence also depends on dose. The highest dose used in people caused drowsiness that lasted about 10 hours, the researchers report.
Note: To comment, Science News subscribing members must now establish a separate login relationship with Disqus. Click the Disqus icon below, enter your e-mail and click “forgot password” to reset your password. You may also log into Disqus using Facebook, Twitter or Google.