Rare marrow cells tackle deadly immune reaction
By Ben Harder
From Atlanta, at a meeting of the American Society of Hematology
Blood-making stem cells taken from a healthy person’s bone marrow can give patients a fighting chance against aggressive blood cancers, but the treatment may also attack the patient’s tissues.
In an attempt to counter this usually lethal complication, known as graft-versus-host disease (GVHD), Katarina LeBlanc of the Karolinska Institute in Stockholm and her colleagues transfused a second kind of marrow-derived cell into 16 patients with GVHD. These cells, known as mesenchymal stem cells, normally give rise to bone, cartilage, and fat cells, but “they also have an ability to turn the immune system off, to dampen inflammation,” LeBlanc says.