Reports that a heart disease–causing version of a gene had been corrected remain contested
When researchers announced last year that they had edited human embryos to repair a damaged gene that can lead to heart failure, critics called the report into question.
Now new evidence confirms that the gene editing was successful, reproductive and developmental biologist Shoukhrat Mitalipov and colleagues report August 8 in Nature. “All of our conclusions were basically right,” Mitalipov, of Oregon Health & Science University in Portland, said during a news conference on August 6.
But authors of two critiques published in the same issue of Nature say they still aren’t convinced.
At issue is the way that the gene was repaired. Mitalipov and colleagues used the molecular scissors CRISPR/Cas9 to cut a faulty version of a gene called MYBPC3