In 1967, LSD was briefly labeled a breaker of chromosomes | Science News



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50 Years Ago

In 1967, LSD was briefly labeled a breaker of chromosomes

Excerpt from the April 1, 1967, issue of Science News

7:00am, March 23, 2017
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LONG, STRANGE TRIP  LSD briefly got tagged as a gene breaker a half century ago before getting a reprieve. Researchers are still trying to figure out how this substance triggers intense, long-lasting hallucinations.

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LSD may damage chromosomes

Two New York researchers have found the hallucinogenic drug will markedly increase the rate of abnormal change in chromosomes. [Scientists] tested LSD on cell cultures from the blood of two healthy individuals … [and] also found similar abnormal changes in the blood of a schizophrenic patient who had been treated with [LSD]. The cell cultures showed a two-fold increase in chromosomal breaks over the normal rate. — Science News, April 1, 1967


Psychedelic-era reports that LSD damages chromosomes got lots of press but fell apart within a few years. A review in Science in 1971 concluded that ingesting moderate doses of LSD caused no detectable genetic damage. Researchers are still trying to figure out the molecular workings of the drug. Recent evidence suggests that the substance gets trapped in a pocket of the receptor for serotonin, a key chemical messenger in the brain. Its prolonged stay may explain why LSD trips can last up to a day or more (SN: 3/4/17, p. 16).


LSD may damage chromosomes. Science News. Vol. 91, April 1, 1967, p. 312.

N. Dishotsky et al. LSD and genetic damage. Science. Vol. 172, April 30, 1971, p. 431. doi: 10.1126/science.172.3982.431.

Further Reading

M. Rosen. LSD’s grip on brain protein could explain drug’s long-lasting effects. Science News. Vol. 191, March 4, 2017, p.16.

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