Archaea microbes fold, twist and contort their DNA in extreme ways
The maneuvers could help these single-celled organisms get easy access to their genes
Single-celled archaea microbes pack their DNA into flexible coils that expand and stretch much like a Slinky does. This kind of molecular gymnastics had never been seen before in other organisms and may represent a way for archaea to get easy access to their genetic material, researchers report March 2 in eLife.
Some of the observed structures “really look like you take a Slinky and force it open, like a book,” says Karolin Luger, a Howard Hughes Medical Institute investigator at the University of Colorado Boulder. “You would think that this would really contort the DNA in an awful shape, but it actually flows very naturally.”
Similar to the cassette tapes she grew up listening to, DNA stores information in a very thin and fragile filament of nucleic acids, says Luger. But unlike the tapes, which often tangled and tore, rendering them useless, the genetic material can be read, split into two like a zipper and replicated without tangles and breaks –– all while remaining confined in an incredibly small compartment.
In 2017, Luger and her colleagues discovered that archaea — microbes that resemble bacteria under the microscope but are quite distinct — can spool their DNA around small proteins called histones (SN: 8/10/17). This process is strikingly similar to how plants, animals and fungi bend and fold their own genomes into compact, disk-shaped units known as nucleosomes.