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Genes & Cells

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3:19pm, July 15, 2011

New mutations in schizophrenia
New genetic errors crop up more often in people with schizophrenia than in their parents. The results may indicate that many cases of schizophrenia arise spontaneously from the new mutations and are not the result of many inherited genes working in concert. An international group of researchers decoded the genetic blueprints of 14 people with schizophrenia and of those people’s parents. The team examined only protein-producing genes, which constitute a tiny fraction of the genetic instructions, but found 15 new mutations in eight of the people with schizophrenia. People with schizophrenia develop new mutations at more than twice the rate of the average person, the researchers report online July 10 in Nature Genetics. —Tina Hesman Saey

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