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Memories lost and found

Drugs that help mice remember reveal role for epigenetics in recall

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2:43pm, July 11, 2013

For nearly a decade, neuro­scientist Li-Huei Tsai and her colleagues have been studying senile mice. In a lab at MIT her team has genetically fast-forwarded the mice into a condition much like dementia: They have problems making new memories and retrieving old ones. The mice forget how to navigate water mazes they had mastered; they don’t recognize signs of imminent danger they had once responded to fearfully.

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