Nerve cell miswiring linked to depression
Mouse study identifies gene needed for proper assembly of serotonin circuitry
Researchers have pinpointed a gene that keeps important brain cells in mice from crossing their wires, providing a possible link between brain wiring and mood disorders like depression.
Without the gene, called Pcdhαc2, mice acted more depressed, researchers report April 28 in Science.
Nerve cells, or neurons, that produce the chemical messenger molecule serotonin extend long projections called axons to various parts of the brain. Serotonin released from the tips of the axons signal other neurons in these target areas to influence mood and other aspects of behavior. For efficient signaling, the axon tips must be properly spaced.