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Norovirus can play protective role in mice

Infection can help intestines develop, strengthen immune system

1:29pm, November 19, 2014
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Even a nasty “stomach bug” may have a good side.

Noroviruses are best known for the diarrhea and vomiting they produce in people. But a mouse norovirus can do the work of friendly gut bacteria to protect the intestines and boost the immune systems of mice, researchers from New York University School of Medicine report November 19 in Nature. The findings add to other studies suggesting that some of the many viruses infecting people and animals can help, not hurt (SN: 1/11/14, p. 18).

Previous research has shown that in mice raised without any gut microbes, the intestines don’t develop properly and the immune system is frail. A two-week course of antibiotics that kills gut bacteria can also weaken the immune system and lead to thin intestinal lining, the researchers found. Several different strains of norovirus could reverse those problems.

Norovirus also helped fight a disease-causing bacterium called Citrobacter rodentium


E. Kernbauer, Y. Ding and K. Cadwell. Anenteric virus can replace the beneficial function of commensal bacteria. Nature. Published online November 19, 2014. doi:10.1038/nature13960.

Further Reading

T. H. Saey. The vast virome. Science News. Vol. 185, January 11, 2014, p. 18.

T. H. Saey. Viruses and mucus team up to ward off bacteria. Science News Online, May 20, 2013.

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