Ovulation spurred by newfound semen ingredient
Growth-boosting protein may act as pregnancy-protecting hormone in humans
By Meghan Rosen
Semen doesn’t just ferry sperm. It also bears a mystery ingredient that turns on ovulation in some animals and may even pump up fertility in humans as well. The molecule, nerve growth factor, kick-starts egg release and revs up pregnancy-protective hormones in llamas, researchers report online August 20 in the Proceedings of the National Academy of Sciences. Llama semen is loaded with NGF, says study coauthor and veterinarian Gregg Adams of the University of Saskatchewan in Saskatoon, Canada. The protein is also found in the semen of bulls and humans.
“If we find that NGF is also effective in women, it will obviously have huge implications for treating male infertility conditions,” says reproductive biologist Raj Duggavathi of McGill University’s campus in Sainte-Anne-de-Bellevue, Canada. “It could be a big boost for couples.”
NGF is well-known to biologists but not in the context of reproduction. Nerve cells typically spit the protein out to tell neighboring cells to grow.