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Three gene variants boost diabetes risk

10:42am, June 21, 2006

From Washington, D.C., at a meeting of the American Diabetes Association

In a large study, researchers have linked small variations in three genes to type 2 diabetes. The information may prove useful in the development of a screening method to determine who is most likely to develop the disease.

Earlier, smaller studies had associated the three gene variants with type 2 diabetes. Valeriya Lyssenko of Lund University in Malmö, Sweden, and her colleagues set out to determine whether detecting common forms, or alleles, of nine diabetes-linked genes could predict who would develop the disease among a large population.

For their study, the researchers randomly selected 7,061 men and women who were participants in the Malmö Preventive Project, a massive, long-term clinical trial that began in the 1970s and followed each person for about 22 years. Lyssenko's team collected each person's medical history and studied analyses of their DNA. Almost 1,500 pe

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