Oocyte success raises hopes for infertility treatments
C. Wu et al/Molecular Therapy 2017
With an assist, an old mouse might be able to make new eggs.
Sterilized female mice produced healthy babies after receiving a transplant of egg-generating stem cells from another mouse, researchers report online May 18 in Molecular Therapy. If such a procedure worked in humans — still a distant prospect — it could help women with early menopause or chemotherapy-induced infertility to conceive.
These egg-generating cells are germline stem cells — precursors that become either eggs or sperm depending on whether they end up in ovaries or testes. While male germline stem cells differentiate (or become specialized) throughout a man’s life to produce a steady supply of new sperm, a woman’s are believed to differentiate into a stockpile of eggs during a relatively narrow time frame before she’s even born. Some recent studies