Bone regulators moonlight in the brain as fever inducers

Study in mice suggests proteins could be source of post-menopausal hot flashes

2:37pm, November 25, 2009

Beauty may be only skin deep, but hot goes to the bone.

Proteins involved in breaking down bones are also part of the body’s thermostat, a new study shows. The proteins — a receptor called RANK and the protein that binds to it, called RANKL — turn up the heat to cause fever during infections and also help regulate daily temperature rhythms in female rodents, a study published in the Nov. 26 Nature shows.

And the proteins, which are involved in osteoporosis, may also be a source of the hot flashes that post-menopausal women experience.

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