A lack of circular RNAs may trigger lupus

Balancing levels of these molecules could help rein in an overactive immune system

3D circular RNA

CIRCLING LUPUS  A three-dimensional image of a circular RNA reveals several places where the normally single-stranded molecule forms double strands. Those regions may be important for regulating some immune reactions. 

C.-X. Liu et al/Cell 2019

A lack of certain mysterious genetic molecules may spin the immune system out of control and lead to lupus.