2,462 results
2,462 results for: mutations
- Health & Medicine
Silencing a gene slows breast-tumor fighter
The protein encoded by the HOXA5 gene plays a key role in fighting breast cancer, helping to switch on cancer-suppressing genes.
- Health & Medicine
Gene stifled in some lung, breast cancers
The silencing of a gene called RASSF1A appears to increase the risk of cancer, studies of lung and breast tumors show.
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Anticancer Protein Locks onto DNA
The protein encoded by the normal form of BRCA1 attaches to DNA directly, seeks out unusual DNA structures, and joins multiple DNA strands together—all activities suggesting a direct role in DNA repair.
- Health & Medicine
New drug takes on intestinal cancer
Imatinib mesylate, already approved by the FDA for treating people with a form of leukemia, blocks the activity of certain enzymes that cause gastrointestinal stromal cells to replicate uncontrollably.
- Health & Medicine
Genetic flaw found in painful gut disease
Scientists have discovered a genetic mutation that occurs in people with Crohn's disease, a digestive disorder that attacks the intestines.
- Health & Medicine
Heart disease linked to clotting gene
African Americans with a mutation in a blood-clotting gene have a sixfold increase in the risk of heart disease, but this is not the case for white Americans with the same mutation.
- Health & Medicine
Genetically altered cells ease hemophilia
A gene therapy using skin cells that are genetically modified to make clotting proteins, multiplied in a lab, and reinjected into a person eases some bleeding in patients with severe hemophilia.
- Health & Medicine
Leukemia overpowers drug in two ways
Researchers discover why the anticancer drug Gleevec, also called STI-571, helps many patients who have chronic myelogenous leukemia but not those who have entered the crisis stage of the disease.
- Health & Medicine
Have a heart: Turn on just a single gene
One gene appears to act as the master switch in embryonic heart formation.
- Health & Medicine
Radiation harms blood vessels before gut
The side-effects of radiation therapy may result from initial damage to blood vessels.
- Health & Medicine
Herpes virus homes in on cancer target
Herpes simplex virus 1 has an affinity for cells with a mutation that marks many tumors, indicating how the virus may be refined as a cancer therapy and that certain new drugs might attack herpes itself.
- Health & Medicine
Gene implicated in deadly influenza
A strain of influenza virus that struck in Hong Kong in 1997 got some of its lethality from a mutation in the gene encoding an enzyme called PB2.
