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  • News

    Genetic risk of getting second cancer tallied for pediatric survivors

    WASHINGTON — A second cancer later in life is common for childhood cancer survivors, and scientists now have a sense of the role genes play when this happens. A project that mined the genetic data of a group of survivors finds that 11.5 percent carry mutations that increase the risk of a subsequent cancer.

    “We’ve always known that among survivors, a certain population will experience...

    04/07/2017 - 13:00 Cancer, Biomedicine, Genetics
  • News in Brief

    Engineered immune cells boost leukemia survival for some

    WASHINGTON — Immune cells engineered to hunt and destroy cancer cells may help some people with acute lymphoblastic leukemia (ALL) live much longer.

    Outcomes depended upon disease severity before treatment, oncologist Jae Park reported April 3 at the American Association for Cancer Research annual meeting.

    In ALL — expected to strike 5,970 people and kill 1,440 in the United States...

    04/04/2017 - 15:30 Cancer, Biomedicine
  • News

    Random mutations play large role in cancer, study finds

    Researchers have identified new enemies in the war on cancer: ones that are already inside cells and that no one can avoid.

    Random mistakes made as stem cells divide are responsible for about two-thirds of the mutations in cancer cells, researchers from Johns Hopkins University report in the March 24 Science. Across all cancer types, environment and lifestyle factors, such as smoking and...

    03/23/2017 - 14:00 Cancer, Cells, Health
  • Feature

    Cancer cells cast a sweet spell on the immune system

    Shrink yourself small enough to swoop over the surface of a human cell, and you might be reminded of Earth’s terrain. Fats, or lipids, stay close to the surface, like grasses and shrubs. Proteins stand above the shrubs, as mighty oaks or palm trees. But before you could distinguish the low-lying lipids from the towering proteins, you’d see something else adorning these molecules — sugars.

    ...
    03/21/2017 - 12:00 Cancer, Immune Science
  • Science Stats

    Colorectal cancer is on the rise among younger adults

    In recent years, rates of colorectal cancer cases and deaths in the United States rose among young and middle-aged adults, an American Cancer Society study of colorectal cancer trends between 2000 and 2014 finds. That increase came even as rates of colon and rectal tumors and deaths dropped in people 50 and older, researchers report online March 1 in CA: A Cancer Journal for Clinicians.

    ...

    03/01/2017 - 17:16 Health, Cancer
  • Feature

    Instead of starving a cancer, researchers go after its defenses

    Like many living things, a cancer cell cannot survive without oxygen. When young and tiny, a malignancy nestles inside a bed of blood vessels that keep it fed. As the mass grows, however, its demand for oxygen outpaces supply. Pockets within the tumor become deprived and send emergency signals for new vessel growth, a process called angiogenesis. In the 1990s, a popular cancer-...

    02/22/2017 - 12:32 Cancer, Cells, Biomedicine
  • News

    Cancer studies get mixed grades on redo tests

    An effort to reproduce findings of five prominent cancer studies has produced a mixed bag of results.

    In a series of papers published January 19 in eLife, researchers from the Reproducibility Project: Cancer Biology report that none of five prominent cancer studies they sought to duplicate were completely reproducible. Replicators could not confirm any of the findings of one study. In...

    01/18/2017 - 16:42 Science & Society, Cancer
  • News

    Cells avoiding suicide may play role in spread of cancer

    SAN FRANCISCO — Mostly dead is still partly alive, even for cells on the brink of suicide, new research suggests.

    Near-death experiences may play a role in embryo development and help cancer cells that survive chemotherapy spread throughout the body, Denise Montell, a cell biologist at the University of California, Santa Barbara, reported December 6 at the annual meeting of the American...

    12/09/2016 - 11:51 Cells, Cancer
  • News in Brief

    Having an extra chromosome has a surprising effect on cancer

    SAN FRANCISCO — Having an extra chromosome may suppress cancer, as long as things don’t get stressful, a new study suggests. The finding may help scientists unravel a paradox: Cells with extra chromosomes grow slower than cells with the usual two copies of each chromosome, but cancer cells, which grow quickly, often have additional chromosomes. Researchers have thought that perhaps extra...

    12/07/2016 - 16:31 Cells, Cancer, Genetics
  • Science Ticker

    Chinese patient is first to be treated with CRISPR-edited cells

    Chinese scientists have injected a person with CRISPR/Cas9-edited cells, marking the first time cells altered with the technique have been used in humans. Researchers used the powerful gene editor to alter immune cells to fight lung cancer, Nature reports November 15.

    Immune cells called CAR-T cells have already been engineered using other gene-editing technologies. A baby’s leukemia was...

    11/16/2016 - 07:00 Clinical Trials, Cancer, Genetics