Altered microbes make an alcohol not produced naturally
Researchers have designed an entire molecular “assembly line” in bacterial cells that pieces together a kind of alcohol that isn’t normally made by known living organisms. This alcohol could serve as a biofuel that, unlike ethanol, has a high energy density and could be used in gasoline and jet fuel.
While the engineered bacteria are not yet efficient enough to produce biofuel on a commercial scale, the work shows that microbes can be designed to make chemicals that are beyond life’s natural repertoire, the researchers report online December 8 in Proceedings of the National Academy of Sciences.
“Previous metabolic engineering work typically produces compounds that already exist in nature,” says coauthor James Liao, a biomolecular engineer at the University of California, Los Angeles. “Our work here aims to produce compounds that are not synthesized in nature.”
Since the 1970s, scientists have been able