Post-stroke shifts in gut bacteria could cause additional brain injury | Science News

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Post-stroke shifts in gut bacteria could cause additional brain injury

Mouse study suggests fecal transplants as therapy

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5:00pm, July 12, 2016
T-cell cycles

VICIOUS CYCLE  After a brain injury, the guts become temporarily paralyzed. That alters gut microbe populations, triggering the activity of pro-inflammatory T cells, which cause further damage in the brain, mouse studies show.  

When mice have a stroke, their gut reaction can amp up brain damage.

A series of new experiments reveals a surprising back-and-forth between the brain and the gut in the aftermath of a stroke. In mice, this dickering includes changes to the gut microbial population that ultimately lead to even more inflammation in the brain.

There is much work to be done to determine whether the results apply to humans. But the research, published in the July 13 Journal of Neuroscience, hints that poop pills laden with healthy microbes could one day be part of post-stroke therapy.

The work also highlights a connection between gut microbes and brain function that scientists are only just beginning to understand,says Ted Dinan of the Microbiome Institute at the University College Cork, Ireland. There’s growing evidence that gut microbes can influence how people experience stress or depression,

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