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This itch-triggering protein also sends signals to stop scratching

Mice lacking the TRPV4 protein scratch less frequently but can’t stop once they start

A black mouse with a white belly and face is hunched over with its front paws raised to its ears as it scratches an itch

A study in mice may have solved the molecular mystery of why scratching relieves an itch.

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By Tina Hesman Saey

People who can’t stop scratching itches may finally have a culprit to blame.

In mice (and probably people), a protein called TRPV4 is involved both in starting an itch and stopping it after scratching, says neuroscientist Roberta Gualdani.