Osteocalcin may well be the answer to the startling, nearly three-times-stronger glucose control observed in downhill walkers, compared with people walking uphill (SN: 12/11/04, p. 380). The eccentric exertion of downhill walking could be stimulating more osteocalcin release from osteoblasts. Members of our burgeoning prediabetic civilization may be inspired to generate their own osteocalcin by walking down hills, stairs, and even treadmills.

Jay Chapman
Pulaski, N.Y.