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Hot or cold? Debate on protein heats up

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10:06am, January 21, 2004
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The pungency of wasabi, horseradish, brussels sprouts, and mustards comes from compounds called isothiocyanates. Applying those same compounds to a person's skin can cause pain and inflammation.

Isothiocyanates activate pain-signaling neurons by triggering a cell-surface protein that lets ions into cells, David Julius of University of California, San Francisco and his colleagues report in the Jan. 15 Nature. Julius' group had previously shown that capsaicin, the compound that gives chili peppers their spicy kick, activates a different but related ion channel (SN: 11/8/97, p. 297). Curiously, the active ingredient in marijuana triggers the same ion channel that the isothiocyanates do, the researchers found.

In another twist, Julius and his colleagues tried but failed to confirm another group's claim that this protein also enables some nerve cells to respond to painfully cold temperatures (SN: 5/10/03, p. 301: Available to subscribers at Second cold-sensing protein found).

"We don't really know why our results differ," Julius says. Studies of sensory nerves from mice genetically engineered to lack the protein may resolve its roles, he adds.

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