Supplement alters metabolism of skin bacteria, causing inflammation, acne
V. Altounian/Science Translational Medicine
Vitamin B12 causes a normal skin bacteria to produce pimple-promoting chemicals.
Both people with clear skin and those with acne have Propionibacterium acnes living on their skin. But bacteria from acne sufferers have a different metabolism than microbes from the pimple-free, researchers report June 24 in Science Translational Medicine. Microbes from the acne-ridden have 109 genes that are more active than normal and 27 that are less active. Taking vitamin B12 can cause similar changes in these bacteria, the researchers found.
Vitamin B12, which is important for making red blood cells and for brain function, has long been known to cause acne in some people, but researchers didn’t understand why. Dezhi Kang of the UCLA David Geffen School of Medicine and colleagues gave vitamin B12 supplements to 10 people with clear skin. One developed acne a week later.