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Resveratrol’s anticancer benefits show up in low doses

Small amounts of the compound found in red wine and grapes prove protective against colon cancer in mice

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2:00pm, July 29, 2015

A LITTLE DROP WILL DO YOU  A little resveratrol may go a long way toward preventing colon cancer. Small doses of the chemical found in red wine and grapes may be better than big ones, researchers find. Researchers caution, however, against tippling: Alcohol in wine actually promotes colon cancer.

Less can be more.

Low doses of resveratrol, a chemical found in red grapes and some other foods, were better than higher ones at stimulating cancer-fighting processes, researchers report July 29 in Science Translational Medicine. Mice with a genetic predisposition for colon cancer also developed fewer tumors on a low dose of the drug than they did on a higher dose. The effect was noticeable when the mice ate a high-fat diet.

Researchers have long known that chemicals’ actions can vary widely at different doses (SN: 1/20/07, p. 40). But those findings haven’t percolated into most clinical studies of drugs or dietary nutrients, says John Pezzuto, a pharmaceutical scientist at Long Island University in New York. Researchers typically determine the maximum dose that people or animals can

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