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Gene regulation makes the human

A stretch of non-coding DNA revs up genes during development

1:02pm, September 4, 2008

Genes alone don’t make the man — after all, humans and chimps share roughly 98 percent of their DNA. But where, when and how much genes are turned on may be essential in setting people apart from other primates.

A stretch of human DNA inserted into mice embryos revs the activity of genes in the developing thumb, toe, forelimb and hind limb. But the chimp and rhesus macaque version of this same stretch of DNA spurs only faint activity in the developing limbs, reports a new study in the Sept. 5 Scie

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