Mood Meds’ Second Wind: Depression drugs aided by extra treatment step

A second, modified course of drug treatment fosters recovery in a substantial minority of depressed adults who don’t feel better after treatment with a commonly prescribed antidepressant, according to a federally funded investigation.

Among depressed patients who didn’t improve on the antidepressant citalopram (Celexa), one in four became virtually symptomfree by switching from citalopram to a second antidepressant.