Switching Off Pain: Modeling relief on the action of marijuana

11:01am, August 13, 2003

Scientists have long known that tetrahydrocannabinol (THC), the active ingredient in marijuana, is an effective painkiller. But THC's kaleidoscopic effects, including sedation, giddiness, and paranoia, limit its use in medicine. Now, researchers have fabricated a drug that alleviates pain through a mechanism similar to that of THC, but without the side effects.

The drug, dubbed AM1241, binds to one of the two types of cannabinoid receptors in the body. These protein-based switches, which sit on a cell's exterior, respond primarily to THC.

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