Vaccinated man excretes live poliovirus for nearly 3 decades

Strains in immune-compromised Briton differ slightly from vaccine’s

poliovirus

CHANGING FACE  An immunodeficient man has been excreting live poliovirus for 28 years. His viral strains differ from the one he received in a vaccine. A simulated virus particle shows some of these changes, in surface regions (red) that interact with human immune proteins and elsewhere (blue).   

G. DUNN ET AL/PLOS PATHOGENS 2015 (CC BY 4.0)

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