Cleansed of cells and repopulated anew, organ successfully produces urine
By stripping a kidney of its cells and repopulating it with new ones, scientists have shown in a rat that a bioengineered kidney can function to some extent like a normal one. The work, published April 14 in Nature Medicine, reveals that the protein scaffold of a kidney provides the architecture and chemical cues that new cells need to adopt the roles of kidney cells.
The results may one day assist in alleviating the transplant organ shortage by providing patients with refurbished kidneys. If bioengineering can make use of kidney scaffolds that come from animals or cadavers