Latest Issue of Science News

5/2/15 Cover

News

Brief diet alters gene activity

By
6:22pm, September 11, 2001

Researchers have known for years that cutting animals' food intake by about one-third extends the creatures' life spans (SN: 3/15/97, p. 162: http://www.sciencenews.org/sn_arc97/3_15_97/bob1.htm).

Using DNA-coated glass chips, researchers have begun ferreting out the shifting genetic activity that accompanies this drastic dietary effect.

Investigators have now compared the 11,000 genes in the livers of mice eating freely with those in rodents on short-term and long-term diets. Genes implicated in inflammation, cell stress, and other contributors to aging increased their activity in older nondieting mice, Stephen R. Spindler of the University of California, Riverside and his colleagues report in the Sept. 11 Proceedings of the National Academy of Sciences.

This article is available only to subscribing members. Join SSP today or Log in.

More from Science News