Some melanoma cancer cells may punch their way through the body
Cell membrane protrusions called “blebs” act as fists to help melanoma cells tunnel

A cancer cell (blob at right in this 3D rendering) can “punch” its way through a tunnel of tissue (yellow) by extending and retracting blebs (red) through cytoskeletal cracks.
M.K. Driscoll et al/Developmental Cell 2024