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Do acid blockers let microbes reach the colon?

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12:59pm, October 17, 2006

Suppressing stomach acid while taking antibiotics may allow antibiotic-resistant bacteria to colonize the intestines, a study shows.

Researchers had previously linked stomach-acid suppression to pneumonia (SN: 10/30/04, p. 277: Available to subscribers at Affairs of the Heartburn: Drugs for stomach acid may hike pneumonia risk). To test the effect of acid-suppressing drugs on bacteria passing through the stomach to the intestines, researchers gave mice two kinds of live, resistant bacteria via a feeding tube over 3 days. The animals then received an acid-suppressing drug, the antibiotic clindamycin, or both. The acid blocker was a proton-pump inhibitor called pantoprazole.

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