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Gene profiles might guide chemotherapy

2:16pm, June 17, 2003

From Chicago, at a meeting of the American Society of Clinical Oncology

Profiles of genetic variations in cancer patients could help oncologists predict the outcome of chemotherapy and, in some cases, indicate the most effective course of treatment, two new studies suggest.

Sarada Gurubhagavatula of Massachusetts General Hospital in Boston and her colleagues analyzed blood from 103 patients who had received chemotherapy for advanced lung cancer. The scientists looked for variations in two genes, dubbed XPD and XRCC1, that encode proteins governing DNA repair.

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