Male DNA found in female brains

Discovery suggests fetal cells can slip through blood-brain barrier

4:54pm, September 28, 2012

Children live on in their mothers’ brains for decades, and not just as memories. Scientists have found pockets of male DNA, presumably from boy fetuses, in the brain tissue of women who died in their 70s.

Not only is male DNA present in women’s brains, it’s common, researchers report online September 26 in PLOS ONE. J. Lee Nelson of the Fred Hutchinson Cancer Research Center in Seattle and her colleagues found snippets of a male-only gene in the brains of 18 of 26 women who died without neurological disease. The male DNA was spread throughout their brains.

The technique used in the study couldn’t distinguish if the DNA was from intact, functional brain cells, though in a separate test of brain tissue from a different woman, Nelson and colleagues did spot nuclei from male cells in the brain. Earlier studies in mice hinted that these foreign cells can integrate themselves into the brain and start functioning as nerve cells.

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