Nerve cells that control overeating are distinct from those active in normal feeding, study shows
Courtesy of Edward Nieh/MIT
Manipulating specific sets of brain cells can quash a mouse’s overindulgence of sugar.
The cells are part of a previously unknown brain circuit that controls compulsive sugar consumption in mice, researchers report in the Jan. 29 Cell. This circuit appears to be distinct from the one that controls normal eating, suggesting that it could be a target for treating obesity caused by overeating in humans.
“One of the biggest challenges with treating obesity that comes with compulsive overeating disorder is that most treatments are just a Band-Aid, treating the symptoms instead of the core problems,” says MIT neuroscientist Kay Tye. “The real underlying problems are the cravings that lead to compulsive eating and the behavior of compulsive overeating itself.”