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Replacing microRNA for cancer treatment

Inserting a missing molecule in mice may shrink liver tumors or limit their growth

By
2:05pm, June 11, 2009

It’s a simple idea: Treat cancer by finding out what’s absent in a cancer cell and replacing it.

Experiments in mice suggest that inserting one small missing molecule could fight cancer without harming normal tissue, researchers at Johns Hopkins University in Baltimore and the Nationwide Children’s Hospital in Columbus, Ohio, report in a study in the June 12 Cell.

The molecule in this case is a small RNA chain known as a microRNA. MicroRNAs (abbreviated as miRNAs) are involved in a wi

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