A detailed study of six adults
who, as children, had half of their brain removed to treat severe epilepsy, shows
how brains can reorganize and bounce back. As extreme as the surgery is, many
of these people keep or recover language and thinking skills. In a new study,
researchers from Caltech and their colleagues discovered one way the brain
While the six participants
rested in an MRI scanner, researchers measured blood flow in seven brain regions
that handle jobs such as vision, attention and movement. In the experiment, blood
flow served as a proxy for brain activity. When activity in one part of the
brain changes in lockstep with activity in another, that implies that the
regions are working together and sharing information. These are signs of strong
connections, which are thought to be crucial for a healthy brain.
In the six people who had
had hemispherectomies, these seven brain systems seemed to be working normally.
In fact, the connections between those seven systems were even
stronger than such connections in six
people with whole brains, the researchers report November 19 in Cell Reports. Such stronger-than-normal
connections might help explain how these post-surgery brains compensate for
missing parts, the researchers suspect.
Understanding more about how the brain reorganizes itself after a big change could
lead to new approaches to speed people’s recoveries from common brain