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Domestication did horses no genetic favors

Human selection led to more harmful variants in equine DNA

11:29am, December 16, 2014

NOT SO WILD  Thousands of years of serving as human companions has led to damaged DNA, a comparison of ancient and modern horse genomes found.

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Horses have paid a genetic price for becoming human companions, a study of ancient equine DNA suggests. Modern domestic horses have more harmful genetic variants than ancient wild breeds did, researchers have found.

Domesticated horses have no living ancestors, so Ludovic Orlando of the University of Copenhagen and colleagues sequenced the genomes of a 16,000-year-old and a 43,000-year-old horse, both excavated near Krasnoyarsk, Russia. Those ancient horses lived before horses were domesticated. They are not direct ancestors of today’s horses; instead, the horses were on a branch in the equine family tree separate from the ancestors of domesticated breeds and of wild Przewalski’s horses, Orlando and colleagues report December 15 in the Proceedings of the National Academy of Sciences.

Comparing genetic variants from modern horse breeds with the ancient horses, the researchers found that some of traits that make for winning thoroughbreds have been around for tens of thousands of years.

In general, though, domestic horses have more harmful genetic variants than the 43,000-year-old horse did. The buildup in detrimental DNA is not simply due to inbreeding, the researchers found. Instead it is the cost of domestication, in which humans have overridden natural selection by picking animals with desirable traits (as people see them) and unwittingly chosen damaged genes. 


M. Schubert et al. Prehistoric genomes reveal the genetic foundation and cost of horse domestication. Proceedings of the National Academy of Sciences. Published online December 15, 2014. doi: 10.1073/pnas.1416991111.

Further Reading

T.H. Saey. Genes tell tale of cat domestication. Science News. Vol. 186, December 13, 2014, p. 7.

T.H. Saey. Ancient horse's DNA fills in picture of equine evolution. Science News. Vol. 184, July 27, 2013, p. 5.

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