Genetic tweaks manipulate DNA’s loops

Engineering genome shape in nucleus could influence gene activity

DNA folds

BENT INTO SHAPE  A strand of DNA folds into globules (pink and blue) as it threads through two bundles of proteins called extrusion complexes (yellow), this new simulation shows. 

Najeeb Marc Tarazi, Adrian Sanborn, E.L. Aiden

By tweaking parts of the genome, scientists have changed how DNA crams itself into a cell’s nucleus.