Mom’s eggs execute Dad’s mitochondria

In “Hamlet,” Rosencrantz and Guildenstern deliver a letter to the rulers of England that carries the ill-fated duo’s own death sentence. Perhaps Shakespeare knew a bit about reproductive biology.

Inside a fertilized egg, with its two sets of chromosomes (blue), the protein ubiquitin (red) tags sperm mitochondria (yellow). Sutovsky et al./Nature

Scientists have now found that during a sperm’s creation, its mitochondria energy-producing units that power all cells acquire molecular tags that mark them for destruction once the

sperm fertilizes an egg.