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New technique gives see-through view into mouse brains

Replacing fatty molecules turns organs transparent

By
12:54pm, April 10, 2013

To usher in a big advance in brain imaging, scientists simply had to cut the fat. By subbing out light-blocking fatty molecules, a new technique turns mouse brains almost fully transparent while retaining their structure and nearly all their important molecules, researchers report in the April 11 Nature.

The new method could help researchers image the whole brain and its circuitry while also doing detailed molecular and cellular analyses, says Clay Reid, a neurobiologist at Harvard University and the Seattle-based Allen Institute for Brain Science. “It’s a lovely paper, and it’s somethin

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