Next Line of Defense: New drugs take on resistant leukemia
By Nathan Seppa
In the past few years, the breakthrough drug imatinib has changed chronic myeloid leukemia from a death sentence to a treatable disease. But 17 percent of patients taking the drug, also called Gleevec, become resistant to its protective effects over 5 years, and their cancer recurs.
Now, two experimental drugs pick up where imatinib leaves off. In many patients with chronic myeloid leukemia (CML) that’s impervious to imatinib, the new compounds suppress the malignancy, two studies show.