Nitric oxide may benefit damaged hearts | Science News



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Nitric oxide may benefit damaged hearts

9:14pm, October 18, 2004

From New Orleans, at a meeting of the American Heart Association

A sudden cutoff of oxygen can kill heart tissue and cause a heart attack. Even when blood flow is restored, however, yet another round of damage can occur, this time due to cell-killing swelling and inflammation.

In a new study of mice, breathing low concentrations of nitric oxide for 24 hours after a heart attack decreased the amount of heart-tissue death and scarring by 29 percent.

The treatment also reduced the number and activity of inflammatory white blood cells infiltrating the animals' heart muscle, report Kyung-Han Lee and Anthony Rosenzweig of Massachusetts General Hospital in Boston. They have yet to ascertain whether the nitric oxide treatment actually improved heart function.

Nitric oxide has another advantage. It's known to dilate blood vessels, allowing more blood to flow through them. When inhaled, however, the gas doesn't reduce overall blood pressure.

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