Shutting Off an On Switch: Novel drugs slow two cancers in mice

One way to arrest cancer is to identify a molecule that malignant cells just can’t do without—and then disable it. Researchers now report success with two experimental drugs that target such a protein, which triggers rapid growth and other malignant changes in cancer cells.

In mice, one of the drugs slows multiple myeloma, a lethal bone marrow cancer, and the other limits fibrosarcoma, a tumor of fibrous tissues.