News

Shutting Off an On Switch: Novel drugs slow two cancers in mice

By
10:28am, March 10, 2004

One way to arrest cancer is to identify a molecule that malignant cells just can't do without—and then disable it. Researchers now report success with two experimental drugs that target such a protein, which triggers rapid growth and other malignant changes in cancer cells.

In mice, one of the drugs slows multiple myeloma, a lethal bone marrow cancer, and the other limits fibrosarcoma, a tumor of fibrous tissues. The scientists report their findings in two articles in an upcoming Cancer Cell.

The researchers homed in on the protein called insulinlike growth factor-1 receptor (IGF-1R). Recent studies have linked excess IGF-1R to heightened risks of colon, prostate, breast, lung, and bladder cancers. Although IGF-1R shows up on the surface of healthy cells, it's more common on tumor cells.

This article is available only to subscribing members. Join SSP today or Log in.

More from Science News