Silence of the Xs

Does junk DNA help women muffle one X chromosome?

Here’s a riddle that will stump most people. What do calico cats—those popular felines with a patchwork of orange-red, black, and white fur—have in common with women who lack sweat glands on portions of their bodies? A clue: Calico cats are almost always female.

The women and cats illustrate the remarkable fact that all female mammals are actually mosaics of cells with two different pedigrees.