Experimental drug delivery may improve heart attack treatment
ORLANDO, Fla. — Nanosized gobs containing a blood clot–dissolving drug can seek out trouble spots in the body and break down blockages responsible for heart attacks, Japanese researchers reported November 14 at a meeting of the American Heart Association. The microscopic packaging seems to improve the drug’s potency and might limit its main drawback — a risk of internal bleeding — by focusing its effect at the clot.
Although the technology has been tested only in pigs, some doctors find the early results intriguing. “This could be a tremendous step forward,” said Roger Blumenthal, a cardiologist at the Johns Hopkins University School of Medicine in Baltimore. If it tests well in people, he said, this controllable form of the clot-busting drug, called tPA, might be a boon for heart attack patients in remote areas that lack hospitals equipped to deliver the highest standard of care for heart attacks.
About half of people for