Gene linked to some smokers’ lung cancer

Acquired defects in the FGFR1 gene could play a role in malignancies, study finds

An overproduced receptor protein that shows up in a subset of lung cancers may offer a target of opportunity for new drugs and a glimmer of hope for some patients, researchers report.

Excess amounts of a protein known as FGFR1, or fibroid growth factor receptor 1, often show up in smokers who develop a hard-to-treat form of lung cancer, suggesting that tobacco smoke exposure damages the gene encoding this protein and steers cells toward cancer in some people.