Latest Issue of Science News


Long-lasting liposomes

A coat of nanoparticles can prevent a popular lab-made capsule from fusing with its neighbors in solution and losing its structure, researchers report.

Liposomes are hollow, spherical capsules made from phospholipids, the same components found in cell membranes. They can be used to carry drugs or other biological cargo. But individual liposomes are fragile and tend to fuse into blobs after a couple of days, spilling their contents prematurely in the process, says Steve Granick of the University of Illinois at Urbana-Champaign. "We want to keep them discrete," he says.

Granick and graduate student Liangfang Zhang studded the liposomes with polystyrene particles 20 nanometers (nm) in diameter. The nanoparticles covered about 25 percent of the 200-nm-diameter liposomes.

The enhanced liposomes remained stable in solution for 50 days, the researchers report in the April Nano Letters.

Note: To comment, Science News subscribing members must now establish a separate login relationship with Disqus. Click the Disqus icon below, enter your e-mail and click “forgot password” to reset your password. You may also log into Disqus using Facebook, Twitter or Google.

This article is available only to subscribing members. Join SSP today or Log in.