New transfusion process between young, old mice helps pinpoint effects
J. Rebo et al/Nature Communications 2016
Harmful factors circulating in old blood may be partly responsible for the mental decline that can come with age, a small study in mice suggests.
Irina Conboy of the University of California, Berkeley and colleagues devised a new way to mingle blood in two mice that didn’t involve stitching their bodies together, as in previous experiments (SN: 5/31/14, p. 8). Instead, researchers used a microfluidic device to shuttle blood, a process that precisely controlled the timing and amount of blood transferred between the mice. The method, reported online November 22 in Nature Communications, allows more precise tests of blood’s influence on aging, the researchers believe.
Old mice benefited in some ways from infusions of young blood, experiments with four young-old pairs of mice revealed. With