Pain, numbness, pain

Scientists have pinpointed the trigger that leads to a burning feeling when some anesthetics are administered.

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TRIGGER FOR BURNING General anesthetics excite sensory neurons in the peripheral nervous system. In this mosaic, a neuron is shown with structures of the general gas anesthetics isoflurane (in the upper right) and etomidate (in the lower left). The center spikes indicate that both drugs are pungent, which makes the neurons fire.