Prion mutation yields disease marked by diarrhea

Rare ailment starts in adulthood, attacking gut before brain

FAMILY PEDIGREE  This diagram shows five generations of an extended family beset by a novel genetic mutation that results in misfolded prion proteins and disease. On this chart, black denotes a person who inherited the mutation. White is someone who didn't. Women are circles and men are squares. A deceased person is lined out, and age at the time of death is noted.

Mead et al/NEJM 2013

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